1.
Nucleosides Nucleotides Nucleic Acids
; 25(9-11): 1205-9, 2006.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17065092
RESUMO
A physiologically based pharmacokinetic (PBPK) model to simulate the plasma concentration and 13CO2 exhalation after [2-13C]uracil administration to DPD-suppressed dogs was developed. Simulation using this PBPK model should be useful in clinical situations where DPD-deficient patients at risk are to be detected with [2-13C]uracil as an in vivo probe.
